Glucose-6-Phosphate Dehydrogenase Deficiency

I am intrigued by the intermediary of glucose, Glucose-6-phosphate. After tearing out my hairs dealing with this sucker last week it becomes pretty obvious how important G6P is.

Having a major role in 5 metabolic pathways, it follows than that it is very common in cells. Following along this line of thought, it should also come as no surprise that the most common enzyme deficiency on this planet has to do with G6P. About 400 million people are affected by Glucose-6-phosphate dehydrogenase (G6PD) deficiency which can cause hemolytic anemia. [1]

The enzyme Glucose-6-phosphate dehydrogenase plays a role in the oxidative stage of the Pentose Phosphate Pathway, converting glucose-6-phosphate to 6-phosphoglucono-d-lactone. Not only does this enzyme catalyze the above conversion, a by-product of this conversion is none other than the ever so important NADPH. The whole step uses NADP+ and Mg2+ to produce before mentioned NADPH + H+.[2]

Deficiency of this enzyme causes accumulation of glucose, and a reduction of NADPH. It is suggested that the deficiency of G6PD might be directly related to the high prevalence of diabetes mellitus type 2 and hypertension in African Americans.[3]

It seems that the only treatments for G6PD deficiency are:[4]

* Prevention: avoidance of foods and drugs that may cause hemolysis
* Blood transfusions, dialysis
* Splenectomy (removal of the spleen)
* Folic acid supplementation

When one considers the magnitude of G6PD deficiency as it might be the cause of not only hemolytic anemia, but also hypertension and diabetes mellitus type 2, it comes as a surprise that the only four options for treatment should be a radical surgery, nutritional steps for prevention, or blood transfusions/ dialysis.

I can't help but wonder how come that there are no other treatments available? Is it too big of a problem to solve?

1. http://en.wikipedia.org/wiki/Glucose-6-phosphate_dehydrogenase_deficiency
2. http://www.biochem.arizona.edu/classes/bioc462/462b/glycolysis.html
3. Gaskin RS, Estwick D, Peddi R (2001). "G6PD deficiency: its role in the high prevalence of hypertension and diabetes mellitus". Ethnicity & disease 11 (4): 749–54
4. Treatment. http://en.wikipedia.org/wiki/Glucose-6-phosphate_dehydrogenase_deficiency

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